Humanin
Humanin is a peptide, indexed here under Mitochondrial and longevity-associated peptides.
Identity
| Field | Value |
|---|---|
| Classification | Peptide |
| Primary class | Mitochondrial and longevity-associated peptides |
| CAS registry number | 330936-69-1[1] |
| PubChem CID | 16131438[1] |
| UniProt accession | Unknown No UniProt query was run in v1. |
| Molecular formula | C119H204N34O32S2[1] |
| Molecular weight | 2687.2 g/mol[1] |
| Amino-acid sequence | Unknown Not reported by the PubChem property set retrieved for this record; no sequence database query was run in v1. |
| Reported half-life | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
What the cited literature examines
Humanin is described in the retrieved literature as a mitochondrial-derived peptide. A 2013 Trends in Endocrinology and Metabolism review asks whether it is a harbinger of such peptides, and a 2003 Nature paper reports that it suppresses apoptosis by interfering with Bax activation.
The retrieved set spans neuroprotective and metabolic endpoints. A 2001 Biochemical and Biophysical Research Communications paper reports mechanisms of neuroprotection by the factor in a Swedish mutant model, and a 2003 Proceedings of the National Academy of Sciences paper reports an interaction with insulin-like growth factor binding protein. A 2009 PLoS One paper reports a role as a central regulator of peripheral insulin action, and a 2013 Journal of Molecular Endocrinology paper covers an emerging role in stress responses.
[3, 4, 5, 6, 7, 8]Reported mechanism
A mitochondrial-derived peptide; the retrieved records report suppression of apoptosis through interference with Bax activation and an interaction with insulin-like growth factor binding protein.
[4, 6]Stated in the titles of the cited 2003 Nature and 2003 Proceedings of the National Academy of Sciences papers.
Targets named in the cited records: Bax, insulin-like growth factor binding protein.
FDA application register
A query of the FDA Drugs@FDA application register on 2026-10-09 returned no application records for this compound name. This compound is not approved by the FDA for human use.[2]
Scope statement: this records the result of a single automated query against the openFDA drugsfda endpoint on the stated date. It is not legal advice and is not a jurisdiction-by-jurisdiction legality assessment.
Retrieved 2026-10-09.
Amounts reported in the cited literature
Unknown. No retrieved record in this dataset states an amount, so none is shown. Where an amount is recorded it is what a named study reported administering in its own stated model, in the past tense, and is not a protocol.
No study-reported dose was taken from a source read in v1. Literature-reported values are only recorded where the retrieved citation metadata states the figure.
Adverse effects reported in the cited literature
Unknown. No retrieved record in this dataset reports an adverse effect for this compound, so no row is shown. Absence of a row records the absence of a retrieved report, nothing more.
No adverse-effect row was taken from a source read in v1. Rows are only recorded with the study model named and the reporting citation attached.
Other names
Humanin appears under these other names in the cited records or in common usage. Each one resolves to this page rather than to a separate page of its own.
- HN
- rescue factor humanin
Where this page sits
Research records
Cited research records for Humanin, each with its identifier, the publication type it is indexed as, and the study model stated by its assigned subject headings.
Compounds indexed next to it
- MOTS-c — Mitochondrial and longevity-associated peptides
- Elamipretide — Mitochondrial and longevity-associated peptides
- Epitalon — Mitochondrial and longevity-associated peptides
- FOXO4-DRI — Mitochondrial and longevity-associated peptides
Class page: Mitochondrial and longevity-associated peptides. Full index: all indexed compounds.
Questions this page answers
What does the cited literature examine for Humanin?
Humanin is described in the retrieved literature as a mitochondrial-derived peptide. A 2013 Trends in Endocrinology and Metabolism review asks whether it is a harbinger of such peptides, and a 2003 Nature paper reports that it suppresses apoptosis by interfering with Bax activation.
Which class is Humanin indexed under?
Humanin is indexed under Mitochondrial and longevity-associated peptides. This class groups peptides whose retrieved literature concerns mitochondrial function or ageing endpoints.
What does the FDA application register show for Humanin?
A query of the FDA Drugs@FDA application register on 2026-10-09 returned no application records for this compound name. This compound is not approved by the FDA for human use.
Sources
- PubChem Compound Summary for CID 16131438, Humanin. PubChem, National Library of Medicine (2026). pubchem:16131438
- Drugs@FDA application register query for this compound, no application records returned. U.S. Food and Drug Administration, openFDA drugsfda endpoint (2026). fda:humanin
- Humanin: a harbinger of mitochondrial-derived peptides?. Trends in endocrinology and metabolism: TEM (2013). pmid:23402768
- Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature (2003). pmid:12732850
- Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein. Biochemical and biophysical research communications (2001). pmid:11327724
- Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proceedings of the National Academy of Sciences of the United States of America (2003). pmid:14561895
- Humanin: a novel central regulator of peripheral insulin action. PloS one (2009). pmid:19623253
- The emerging role of the mitochondrial-derived peptide humanin in stress resistance. Journal of molecular endocrinology (2013). pmid:23239898
On each stated value was matched to the record cited for it. That is record matching, not an appraisal of the research. Compiled and checked by: Peptide Monographs editorial desk. No qualified clinical reviewer.