Epitalon
Epitalon is a peptide, indexed here under Mitochondrial and longevity-associated peptides.
Identity
| Field | Value |
|---|---|
| Classification | Peptide |
| Primary class | Mitochondrial and longevity-associated peptides |
| CAS registry number | 307297-39-8[1] |
| PubChem CID | 219042[1] |
| UniProt accession | Unknown No UniProt query was run in v1. |
| Molecular formula | C14H22N4O9[1] |
| Molecular weight | 390.35 g/mol[1] |
| Amino-acid sequence | Unknown Not reported by the PubChem property set retrieved for this record; no sequence database query was run in v1. |
| Reported half-life | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
What the cited literature examines
Epitalon, also written Epithalon, is a short synthetic peptide reported in the retrieved literature as the AEDG peptide. A 2020 Molecules paper reports that it stimulates gene expression and protein synthesis, and a 2003 Bulletin of Experimental Biology and Medicine paper reports induction of telomerase activity and telomere elongation in a human cell model.
Its retrieved records are predominantly rodent and invertebrate ageing and carcinogenesis work. A 2000 Mechanisms of Ageing and Development paper reports an effect on lifespan in Drosophila melanogaster, a 2002 International Journal of Cancer paper reports an inhibitory effect on the development of spontaneous tumours, a 2002 Cancer Letters paper reports an inhibitory effect on induced colon carcinogenesis, and a 2002 Bulletin of Experimental Biology and Medicine paper reports effects on gene expression in mouse tissue.
[3, 4, 5, 6, 7, 8]Reported mechanism
A short synthetic peptide; the retrieved records report stimulation of gene expression and, in a human cell model, induction of telomerase activity.
[3, 4]Stated in the titles of the cited 2020 Molecules and 2003 Bulletin of Experimental Biology and Medicine papers.
Targets named in the cited records: telomerase, gene expression.
FDA application register
A query of the FDA Drugs@FDA application register on 2026-10-09 returned no application records for this compound name. This compound is not approved by the FDA for human use.[2]
Scope statement: this records the result of a single automated query against the openFDA drugsfda endpoint on the stated date. It is not legal advice and is not a jurisdiction-by-jurisdiction legality assessment.
Retrieved 2026-10-09.
Amounts reported in the cited literature
Unknown. No retrieved record in this dataset states an amount, so none is shown. Where an amount is recorded it is what a named study reported administering in its own stated model, in the past tense, and is not a protocol.
No study-reported dose was taken from a source read in v1. Literature-reported values are only recorded where the retrieved citation metadata states the figure.
Adverse effects reported in the cited literature
Unknown. No retrieved record in this dataset reports an adverse effect for this compound, so no row is shown. Absence of a row records the absence of a retrieved report, nothing more.
No adverse-effect row was taken from a source read in v1. Rows are only recorded with the study model named and the reporting citation attached.
Other names
Epitalon appears under these other names in the cited records or in common usage. Each one resolves to this page rather than to a separate page of its own.
- Epithalon
- AEDG peptide
- Ala-Glu-Asp-Gly
Where this page sits
Research records
Cited research records for Epitalon, each with its identifier, the publication type it is indexed as, and the study model stated by its assigned subject headings.
Compounds indexed next to it
- MOTS-c — Mitochondrial and longevity-associated peptides
- Humanin — Mitochondrial and longevity-associated peptides
- Carnosine — Mitochondrial and longevity-associated peptides
- FOXO4-DRI — Mitochondrial and longevity-associated peptides
- Livagen — Short peptide bioregulators
- Pinealon — Short peptide bioregulators
- Testagen — Short peptide bioregulators
Class page: Mitochondrial and longevity-associated peptides. Full index: all indexed compounds.
Questions this page answers
What does the cited literature examine for Epitalon?
Epitalon, also written Epithalon, is a short synthetic peptide reported in the retrieved literature as the AEDG peptide. A 2020 Molecules paper reports that it stimulates gene expression and protein synthesis, and a 2003 Bulletin of Experimental Biology and Medicine paper reports induction of telomerase activity and telomere elongation in a human cell model.
Which class is Epitalon indexed under?
Epitalon is indexed under Mitochondrial and longevity-associated peptides. This class groups peptides whose retrieved literature concerns mitochondrial function or ageing endpoints.
What does the FDA application register show for Epitalon?
A query of the FDA Drugs@FDA application register on 2026-10-09 returned no application records for this compound name. This compound is not approved by the FDA for human use.
Sources
- PubChem Compound Summary for CID 219042, Epitalon. PubChem, National Library of Medicine (2026). pubchem:219042
- Drugs@FDA application register query for this compound, no application records returned. U.S. Food and Drug Administration, openFDA drugsfda endpoint (2026). fda:epitalon
- AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules (Basel, Switzerland) (2020). pmid:32019204
- Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of experimental biology and medicine (2003). pmid:12937682
- Effect of epitalon on the lifespan increase in Drosophila melanogaster. Mechanisms of ageing and development (2000). pmid:11087911
- Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. International journal of cancer (2002). pmid:12209581
- Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer letters (2002). pmid:12049808
- Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology. Bulletin of experimental biology and medicine (2002). pmid:12360356
On each stated value was matched to the record cited for it. That is record matching, not an appraisal of the research. Compiled and checked by: Peptide Monographs editorial desk. No qualified clinical reviewer.