Thymulin
Thymulin is a peptide, indexed here under Endocrine and immune signalling peptides.
Identity
| Field | Value |
|---|---|
| Classification | Peptide |
| Primary class | Endocrine and immune signalling peptides |
| CAS registry number | 78922-62-0[1] |
| PubChem CID | 71300623[1] |
| UniProt accession | Unknown No UniProt query was run in v1. |
| Molecular formula | C33H54N12O15[1] |
| Molecular weight | 858.9 g/mol[1] |
| Amino-acid sequence | Unknown Not reported by the PubChem property set retrieved for this record; no sequence database query was run in v1. |
| Reported half-life | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
What the cited literature examines
Thymulin, reported in the older literature as facteur thymique serique or FTS, is a zinc-dependent nonapeptide of the thymus. A 1985 Proceedings of the National Academy of Sciences paper reports a zinc-dependent epitope on the molecule, a 1988 Journal of Clinical Investigation paper reports serum thymulin in human zinc deficiency, and 1984 European Journal of Immunology papers report in vivo and in vitro studies in marginally zinc-deficient mice and immunohistological evidence for its presence alongside thymopoietin in thymic epithelial cells.
Endocrine control of its secretion recurs in the retrieved set: a 1987 Clinical and Experimental Immunology paper reports that growth hormone stimulates thymulin production in aged dogs, a 1989 Endocrinology paper reports that prolactin stimulates its production, a 1992 Proceedings of the National Academy of Sciences paper reports interleukin 1 regulation of zinc-thymulin secretion, a 1995 International Journal of Immunopharmacology paper reports that zinc induces its secretion from human thymic epithelial cells, and a 2000 Journal of Neuroimmunology paper reports a melatonin-driven nocturnal increase. 1990 and 1994 American Journal of Clinical Nutrition papers report thymulin activity in iron-deficiency anaemia in mice and in severely malnourished children.
[3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13]Reported mechanism
A zinc-dependent thymic nonapeptide; the retrieved records report T-lymphocyte differentiating activity that requires zinc binding.
[3, 13]Stated in the titles of the cited 1985 Proceedings of the National Academy of Sciences and 1994 American Journal of Clinical Nutrition papers.
Targets named in the cited records: T-lymphocyte differentiation, zinc binding.
FDA application register
A query of the FDA Drugs@FDA application register on 2026-10-09 returned no application records for this compound name. This compound is not approved by the FDA for human use.[2]
Scope statement: this records the result of a single automated query against the openFDA drugsfda endpoint on the stated date. It is not legal advice and is not a jurisdiction-by-jurisdiction legality assessment.
Retrieved 2026-10-09.
Amounts reported in the cited literature
Unknown. No retrieved record in this dataset states an amount, so none is shown. Where an amount is recorded it is what a named study reported administering in its own stated model, in the past tense, and is not a protocol.
No study-reported dose was taken from a source read in v1. Literature-reported values are only recorded where the retrieved citation metadata states the figure.
Adverse effects reported in the cited literature
Unknown. No retrieved record in this dataset reports an adverse effect for this compound, so no row is shown. Absence of a row records the absence of a retrieved report, nothing more.
No adverse-effect row was taken from a source read in v1. Rows are only recorded with the study model named and the reporting citation attached.
Other names
Thymulin appears under these other names in the cited records or in common usage. Each one resolves to this page rather than to a separate page of its own.
- facteur thymique serique
- FTS
- Zn-FTS
- serum thymic factor
Where this page sits
Research records
Cited research records for Thymulin, each with its identifier, the publication type it is indexed as, and the study model stated by its assigned subject headings.
Compounds indexed next to it
- Thymosin alpha 1 — Endocrine and immune signalling peptides
- Thymalin — Short peptide bioregulators
Class page: Endocrine and immune signalling peptides. Full index: all indexed compounds.
Questions this page answers
What does the cited literature examine for Thymulin?
Thymulin, reported in the older literature as facteur thymique serique or FTS, is a zinc-dependent nonapeptide of the thymus. A 1985 Proceedings of the National Academy of Sciences paper reports a zinc-dependent epitope on the molecule, a 1988 Journal of Clinical Investigation paper reports serum thymulin in human zinc deficiency, and 1984 European Journal of Immunology papers report in vivo and in vitro studies in marginally zinc-deficient mice and immunohistological evidence for its presence alongside thymopoietin in thymic epithelial cells.
Which class is Thymulin indexed under?
Thymulin is indexed under Endocrine and immune signalling peptides. This class groups peptides whose retrieved literature concerns endocrine or immune signalling outside the growth hormone axis.
What does the FDA application register show for Thymulin?
A query of the FDA Drugs@FDA application register on 2026-10-09 returned no application records for this compound name. This compound is not approved by the FDA for human use.
Sources
- PubChem Compound Summary for CID 71300623, Thymulin. PubChem, National Library of Medicine (2026). pubchem:71300623
- Drugs@FDA application register query for this compound, no application records returned. U.S. Food and Drug Administration, openFDA drugsfda endpoint (2026). fda:thymulin
- A zinc-dependent epitope on the molecule of thymulin, a thymic hormone. Proceedings of the National Academy of Sciences of the United States of America (1985). pmid:2413455
- Serum thymulin in human zinc deficiency. The Journal of clinical investigation (1988). pmid:3262625
- In vivo and in vitro studies of thymulin in marginally zinc-deficient mice. European journal of immunology (1984). pmid:6609827
- Thymic hormone-containing cells VI. Immunohistologic evidence for the simultaneous presence of thymulin, thymopoietin and thymosin alpha 1 in normal and pathological human thymuses. European journal of immunology (1984). pmid:6389155
- Growth hormone treatment stimulates thymulin production in aged dogs. Clinical and experimental immunology (1987). pmid:3652525
- Neuroendocrine control of thymic hormonal production. I. Prolactin stimulates in vivo and in vitro the production of thymulin by human and murine thymic epithelial cells. Endocrinology (1989). pmid:2737149
- Interleukin 1 regulates secretion of zinc-thymulin by human thymic epithelial cells and its action on T-lymphocyte proliferation and nuclear protein kinase C. Proceedings of the National Academy of Sciences of the United States of America (1992). pmid:1502195
- Zinc induces thymulin secretion from human thymic epithelial cells in vitro and augments splenocyte and thymocyte responses in vivo. International journal of immunopharmacology (1995). pmid:8582784
- Melatonin is responsible for the nocturnal increase observed in serum and thymus of thymosin alpha1 and thymulin concentrations: observations in rats and humans. Journal of neuroimmunology (2000). pmid:10696913
- Influence of iron-deficiency anemia on selected thymus functions in mice: thymulin biological activity, T-cell subsets, and thymocyte proliferation. The American journal of clinical nutrition (1990). pmid:2305709
- In vitro lymphocyte-differentiating effects of thymulin (Zn-FTS) on lymphocyte subpopulations of severely malnourished children. The American journal of clinical nutrition (1994). pmid:8030607
On each stated value was matched to the record cited for it. That is record matching, not an appraisal of the research. Compiled and checked by: Peptide Monographs editorial desk. No qualified clinical reviewer.