Research records indexed for MOTS-c
This page carries 12 of the 272 records that the literature query returned for MOTS-c, selected by citation count and preferring records that name the compound in their title. It is a selection, not a complete index, and the 260 records it does not carry are not represented here. Every row resolves to a real identifier and names the study model, so no finding reads as a human claim by default. The compound page is MOTS-c.
Indexed records
| Record | Year | Study type | Model | n as stated | What it reported |
|---|---|---|---|---|---|
| MOTS-c Promotes Glycolysis via AMPK-HIF-1α-PFKFB3 Pathway to Ameliorate Cardiopulmonary Bypass-induced Lung Injury pmid:40035775 | 2025 | Research Support, Non-U.S. Gov't | rodent | Not stated | Indexed as research support, non-u.s. gov't. study model from MeSH "Mice, Inbred C57bl". subject headings: Endothelial Cells; Mice, Inbred C57BL; Reperfusion Injury; Phosphofructokinase-2; Cardiopulmonary Bypass. |
| Novel function of MOTS-c in mitochondrial remodelling contributes to its antiviral role during HBV infection pmid:37788894 | 2024 | Research Support, Non-U.S. Gov't | rodent | Not stated | Indexed as research support, non-u.s. gov't. study model from MeSH "Mice". subject headings: Hepatitis B Virus; Hepatitis B; Hepatitis B, Chronic; Actins; Transcription Factors. |
| The DNA-dependent protein kinase catalytic subunit exacerbates endotoxemia-induced myocardial microvascular injury by disrupting the MOTS-c/JNK pathway and inducing profilin-mediated lamellipodia degradation pmid:38389837 | 2024 | Research Support, Non-U.S. Gov't, research-article | rodent | Not stated | Indexed as research support, non-u.s. gov't, research-article. study model from MeSH "Mice". subject headings: Pseudopodia; Endothelial Cells; Endotoxemia; Heart Injuries; Actins. |
| The mitochondrial genome-encoded peptide MOTS-c interacts with Bcl-2 to alleviate nonalcoholic steatohepatitis progression pmid:38206815 | 2024 | Research Support, Non-U.S. Gov't | rodent | Not stated | Indexed as research support, non-u.s. gov't. study model from MeSH "Mice, Inbred C57bl". subject headings: Liver; Mice, Inbred C57BL; Fibrosis; Inflammation; Transcription Factors. |
| Impact of Radiation Therapy on Serum Humanin and MOTS-c Levels in Patients with Lung or Breast Cancer pmid:38314601 | 2024 | Observational Study | other | Not stated | Indexed as observational study. study model from MeSH "Humans" with no interventional publication type. subject headings: Breast Neoplasms; Lung Neoplasms; Paclitaxel; Intracellular Signaling Peptides And Proteins; Case-Control Studies. |
| Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration pmid:38170165 | 2024 | research-article | rodent | Not stated | Indexed as research-article. study model from MeSH "Mice, Inbred C57bl". subject headings: Muscle, Skeletal; Mice, Inbred C57BL; Muscular Atrophy; Water; Lipids. |
| Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination pmid:39321430 | 2024 | Research Support, Non-U.S. Gov't, research-article | rodent | Not stated | Indexed as research support, non-u.s. gov't, research-article. study model from MeSH "Mice". subject headings: Cell Line, Tumor; Mitochondria; Ovarian Neoplasms; Disease Models, Animal; Disease Progression. |
| Pyrroloquinoline Quinone Alleviates Mitochondria Damage in Radiation-Induced Lung Injury in a MOTS-c-Dependent Manner pmid:39259217 | 2024 | Journal Article | rodent | Not stated | Indexed as journal article. study model from MeSH "Mice, Inbred C57bl". subject headings: Lung; Mitochondria; Mice, Inbred C57BL; Radiation Injuries; PQQ Cofactor. |
| Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging pmid:36670507 | 2023 | Research Support, Non-U.S. Gov't, review-article | other | Not stated | Indexed as research support, non-u.s. gov't, review-article. study model from MeSH "Humans" with no interventional publication type. subject headings: Mitochondria; Insulin Resistance; Peptides; Mitochondrial Proteins; Transcription Factors. |
| MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation pmid:36761202 | 2023 | Research Support, Non-U.S. Gov't, review-article | other | Not stated | Indexed as research support, non-u.s. gov't, review-article. study model from MeSH "Humans" with no interventional publication type. subject headings: Mitochondria; Insulin Resistance; Obesity; Peptides; Transcription Factors. |
| The role of MOTS-c-mediated antioxidant defense in aerobic exercise alleviating diabetic myocardial injury pmid:37957221 | 2023 | Research Support, Non-U.S. Gov't, research-article | rodent | Not stated | Indexed as research support, non-u.s. gov't, research-article. study model from MeSH "Rats". subject headings: Diabetes Mellitus, Type 2; Superoxide Dismutase; Antioxidants; Exercise; Oxidative Stress. |
| The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy pmid:36786072 | 2023 | research-article | other | Not stated | Indexed as research-article. study model from MeSH "Humans" with no interventional publication type. subject headings: Cardiomyopathies; Inflammation; Lipopolysaccharides; Cytokines; AMP-Activated Protein Kinases. |
Where this page sits
Compound page: MOTS-c. Class: Mitochondrial and longevity-associated peptides.
Retrieved 2026-10-10.
Sources
- PubChem Compound Summary for CID 146675088, Mots-c. PubChem, National Library of Medicine (2026). pubchem:146675088
- Drugs@FDA application register query for this compound, no application records returned. U.S. Food and Drug Administration, openFDA drugsfda endpoint (2026). fda:mots-c
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell metabolism (2015). pmid:25738459
- The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell metabolism (2018). pmid:29983246
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature communications (2021). pmid:33473109
- MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free radical biology & medicine (2016). pmid:27216708
- The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?. Aging cell (2015). pmid:26289118
- Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. International journal of cardiology (2018). pmid:29242099
On each stated value was matched to the record cited for it. That is record matching, not an appraisal of the research. Compiled and checked by: Peptide Monographs editorial desk. No qualified clinical reviewer.