Research records indexed for FOXO4-DRI
This page carries 12 of the 17 records that the literature query returned for FOXO4-DRI, selected by citation count and preferring records that name the compound in their title. It is a selection, not a complete index, and the 5 records it does not carry are not represented here. Every row resolves to a real identifier and names the study model, so no finding reads as a human claim by default. The compound page is FOXO4-DRI.
Indexed records
| Record | Year | Study type | Model | n as stated | What it reported |
|---|---|---|---|---|---|
| Acylglycerol Kinase Sensitizes Glioblastoma to Temozolomide via Limiting Mitochondrial Damage Related Cellular Senescence pmid:42391447 | 2026 | Research Support, Non-U.S. Gov't, research-article | other | Not stated | Indexed as research support, non-u.s. gov't, research-article. compound named in the abstract, not the title. study model from MeSH "Animals" with no rodent species heading. subject headings: Cell Line, Tumor; Mitochondria; Glioblastoma; Brain Neoplasms; Reactive Oxygen Species. |
| Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline pmid:42024235 | 2026 | Review | other | Not stated | Indexed as review. compound named in the abstract, not the title. study model from MeSH "Animals" with no rodent species heading. subject headings: Brain; Cell Cycle Proteins; Aging; Tumor Suppressor Protein P53; Forkhead Transcription Factors. |
| The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI pmid:40593617 | 2025 | research-article | other | Not stated | Indexed as research-article. study model from MeSH "Humans" with no interventional publication type. subject headings: Cell Cycle Proteins; Transcription Factors; Protein Binding; Phosphorylation; Models, Molecular. |
| FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation pmid:39994346 | 2025 | research-article | other | Not stated | Indexed as research-article. study model from MeSH "Humans" with no interventional publication type. subject headings: Cells, Cultured; Fibroblasts; Keloid; Serine; Cell Cycle Proteins. |
| FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells pmid:39025385 | 2024 | Journal Article | rodent | Not stated | Indexed as journal article. study model from MeSH "Mice, Inbred C57bl". subject headings: Leydig Cells; Mice, Inbred C57BL; Quinolones; Cell Cycle Proteins; Apoptosis. |
| Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia pmid:37874230 | 2024 | research-article, Research Support, N.I.H., Extramural | rodent | Not stated | Indexed as research-article, research support, n.i.h., extramural. compound named in the abstract, not the title. study model from MeSH "Rats". subject headings: Lung; Animals, Newborn; Rats, Sprague-Dawley; Bronchopulmonary Dysplasia; Disease Models, Animal. |
| Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression pmid:36515093 | 2023 | Research Support, Non-U.S. Gov't | rodent | Not stated | Indexed as research support, non-u.s. gov't. compound named in the abstract, not the title. study model from MeSH "Mice". subject headings: Pulmonary Artery; Endothelial Cells; Hypertension, Pulmonary; Sulfonamides; Aniline Compounds. |
| FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice pmid:37074394 | 2023 | Research Support, Non-U.S. Gov't | rodent | Not stated | Indexed as research support, non-u.s. gov't. compound named in the abstract, not the title. study model from MeSH "Mice, Inbred C57bl". subject headings: Lung; Extracellular Matrix; Fibroblasts; Mice, Inbred C57BL; Pulmonary Fibrosis. |
| FOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice through ECM-receptor interaction pathway pmid:35510614 | 2022 | Research Support, Non-U.S. Gov't, research-article | rodent | Not stated | Indexed as research support, non-u.s. gov't, research-article. compound named in the abstract, not the title. study model from MeSH "Mice, Inbred C57bl". subject headings: Lung; Fibroblasts; Mice, Inbred C57BL; Pulmonary Fibrosis; Disease Models, Animal. |
| Targeting senescence-like fibroblasts radiosensitizes non-small cell lung cancer and reduces radiation-induced pulmonary fibrosis pmid:34877934 | 2021 | Research Support, Non-U.S. Gov't, research-article | rodent | Not stated | Indexed as research support, non-u.s. gov't, research-article. compound named in the abstract, not the title. study model from MeSH "Mice". subject headings: Fibroblasts; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Pulmonary Fibrosis; Radiation Exposure. |
| FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice pmid:31959736 | 2020 | Research Support, Non-U.S. Gov't, research-article | rodent | Not stated | Indexed as research support, non-u.s. gov't, research-article. study model from MeSH "Mice". subject headings: Testis; Leydig Cells; Mitochondria; Testosterone; Cell Cycle Proteins. |
| Rejuvenation by Therapeutic Elimination of Senescent Cells pmid:28340347 | 2017 | Journal Article | other | Not stated | Indexed as journal article. compound named in the abstract, not the title. study model from MeSH "Humans" with no interventional publication type. subject headings: Rejuvenation; Apoptosis; Cell Survival; Tumor Suppressor Protein P53; Cellular Senescence. |
Where this page sits
Compound page: FOXO4-DRI. Class: Mitochondrial and longevity-associated peptides.
Retrieved 2026-10-12.
Sources
- PubChem Compound Summary for CID 167312269, Foxo4-dri. PubChem, National Library of Medicine (2026). pubchem:167312269
- Drugs@FDA application register query for this compound, no application records returned. U.S. Food and Drug Administration, openFDA drugsfda endpoint (2026). fda:foxo4-dri
- The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI. Nature communications (2025). pmid:40593617
- FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation. Communications biology (2025). pmid:39994346
- FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (2020). pmid:31959736
- Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From <i>in vitro</i> Expanded Human Chondrocytes. Frontiers in bioengineering and biotechnology (2021). pmid:33996787
- FOXO4-D-Retro-Inverso targets extracellular matrix production in fibroblasts and ameliorates bleomycin-induced pulmonary fibrosis in mice. Naunyn-Schmiedeberg's archives of pharmacology (2023). pmid:37074394
- FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells. Experimental gerontology (2024). pmid:39025385
- FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway. Frontiers in bioengineering and biotechnology (2025). pmid:41625068
On each stated value was matched to the record cited for it. That is record matching, not an appraisal of the research. Compiled and checked by: Peptide Monographs editorial desk. No qualified clinical reviewer.