Growth factors and growth hormone-derived compounds
Growth factors and growth hormone-derived compounds groups 6 indexed compounds. Also written as IGF-1 analogues, growth hormone derived peptides, myostatin inhibitors.
Definition
This class groups the growth factors, growth factor fragments and growth hormone-derived proteins that research-peptide catalogues list alongside the secretagogues, most of which are proteins rather than peptides and are labelled as such on their pages. A 2010 Endocrinology minireview describes mechano growth factor as a putative product of IGF-I gene expression, a 1989 Biochemical Journal paper describes the des(1-3) form of IGF-I and its escape from IGF-binding proteins, a 1990 Science paper identifies follistatin as the activin-binding protein of rat ovary, and a 1989 New England Journal of Medicine paper reports recombinant human growth hormone in adults with growth hormone deficiency.
[1, 2, 3, 4]Class-level mechanism as reported
The members act on two axes rather than one receptor. The IGF-I derived members act through the IGF-1 receptor: a 2003 Mechanisms of Ageing and Development paper reports des(1-3)IGF-I mediated activation of Akt-1 and p70 S6K in mouse muscle, and a 2011 paper in the same journal reports that the mechano growth factor E peptide activates human muscle progenitor cells. The activin-axis members antagonise myostatin: a 2004 Developmental Biology paper reports that follistatin complexes myostatin and antagonises its inhibition of myogenesis, and a 2017 Muscle and Nerve paper describes ACE-031 as a myostatin inhibitor.
[5, 6, 7, 8]Members
| Compound | Other names | Peptide | Reported half-life |
|---|---|---|---|
| IGF-1 LR3 | Long R3 IGF-I, LR3-IGF-I, long arginine 3 IGF-1 | No | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
| IGF-1 DES | des(1-3)IGF-I, des-IGF-1, truncated IGF-I | No | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
| Mechano growth factor | MGF, MGF peptide, MGF-E peptide | Yes | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
| Follistatin-344 | follistatin, FST, activin-binding protein | No | Withheld pending qualified review |
| ACE-031 | ramatercept, soluble activin type IIB receptor, ActRIIB-Fc | No | Withheld pending qualified review |
| Somatropin | recombinant human growth hormone, rhGH, HGH 191aa | No | Withheld pending qualified review |
3 of 6 compounds in this class are withheld pending qualified review, so their reported values are not shown here and their pages are not published. They are listed because the class is incomplete without them.
Where this page sits
Research records for compounds in this class
- Records indexed for IGF-1 LR3
- Records indexed for IGF-1 DES
- Records indexed for Mechano growth factor
- Records indexed for Follistatin-344
- Records indexed for ACE-031
- Records indexed for Somatropin
All classes: class index. All compounds: compound index.
Sources
- Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration. Endocrinology (2010). pmid:20130113
- Insulin-like growth factor (IGF)-binding proteins inhibit the biological activities of IGF-1 and IGF-2 but not des-(1-3)-IGF-1. The Biochemical journal (1989). pmid:2539101
- Activin-binding protein from rat ovary is follistatin. Science (New York, N.Y.) (1990). pmid:2106159
- The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. The New England journal of medicine (1989). pmid:2687691
- Age-related differences in the des IGF-I-mediated activation of Akt-1 and p70 S6K in mouse skeletal muscle. Mechanisms of ageing and development (2003). pmid:12875741
- Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages. Mechanisms of ageing and development (2011). pmid:21354439
- Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis. Developmental biology (2004). pmid:15136138
- Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial. Muscle & nerve (2017). pmid:27462804
On each stated value was matched to the record cited for it. That is record matching, not an appraisal of the research. Compiled and checked by: Peptide Monographs editorial desk. No qualified clinical reviewer.