Melanocortin receptor peptides
Melanocortin receptor peptides groups 4 indexed compounds. Also written as melanocortin agonists, melanotropic peptides, alpha-MSH analogues.
Definition
Melanocortin receptor peptides are analogues of alpha-melanocyte-stimulating hormone that act at melanocortin receptors. A 2000 International Journal of Impotence Research paper reports human studies with melanocortin receptor agonists, and a 1996 Life Sciences paper describes melanotan-II as a cyclic melanotropic peptide evaluated in a pilot phase I clinical study.
[1, 2]Class-level mechanism as reported
Members differ in receptor selectivity across the melanocortin receptor subtypes, and the retrieved literature separates pigmentary from central effects. A 2015 New England Journal of Medicine trial report covers afamelanotide in erythropoietic protoporphyria, while a 2007 Journal of Sexual Medicine review covers preclinical central nervous system effects of bremelanotide.
[3, 4]Members
| Compound | Other names | Peptide | Reported half-life |
|---|---|---|---|
| Melanotan II | MT-II, MT-2, Melanotan 2 | Yes | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
| Bremelanotide | PT-141, Vyleesi | Yes | Withheld pending qualified review |
| Afamelanotide | melanotan I, Scenesse, NDP-alpha-MSH | Yes | Withheld pending qualified review |
| Setmelanotide | RM-493, Imcivree, BIM-22493 | Yes | Withheld pending qualified review |
3 of 4 compounds in this class are withheld pending qualified review, so their reported values are not shown here and their pages are not published. They are listed because the class is incomplete without them.
Where this page sits
Research records for compounds in this class
- Records indexed for Melanotan II
- Records indexed for Bremelanotide
- Records indexed for Afamelanotide
- Records indexed for Setmelanotide
Side-by-side pages within this class
All classes: class index. All compounds: compound index.
Sources
- Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res (2000). pmid:11035391
- Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci (1996). pmid:8637402
- Afamelanotide for Erythropoietic Protoporphyria. N Engl J Med (2015). pmid:26132941
- Bremelanotide: an overview of preclinical CNS effects on female sexual function. J Sex Med (2007). pmid:17958619
On each stated value was matched to the record cited for it. That is record matching, not an appraisal of the research. Compiled and checked by: Peptide Monographs editorial desk. No qualified clinical reviewer.