Growth hormone secretagogues
Growth hormone secretagogues groups 8 indexed compounds. Also written as ghrelin receptor agonists, GHS, growth hormone releasing peptides.
Definition
Growth hormone secretagogues are compounds that act at the growth hormone secretagogue receptor, the receptor for ghrelin, rather than at the growth hormone releasing hormone receptor. A 2021 Nature Communications paper reports the structural basis of human ghrelin receptor signalling by ghrelin and by the synthetic agonist ibutamoren. Not every member of this class is a peptide.
[1]Class-level mechanism as reported
Agonism at the growth hormone secretagogue receptor is the shared mechanism. A 1998 European Journal of Endocrinology paper describes ipamorelin as the first selective growth hormone secretagogue, and a 2001 Molecular Endocrinology paper examines regulation of Pit-1 expression by ghrelin and GHRP-6 through the growth hormone secretagogue receptor.
[2, 3]Members
| Compound | Other names | Peptide | Reported half-life |
|---|---|---|---|
| Ipamorelin | NNC 26-0161 | Yes | Withheld pending qualified review |
| GHRP-6 | growth hormone releasing peptide 6 | Yes | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
| Hexarelin | examorelin | Yes | Withheld pending qualified review |
| Ibutamoren | MK-677, MK-0677, ibutamoren mesylate | No | Withheld pending qualified review |
| AOD9604 | AOD-9604, hGH fragment 176-191 | Yes | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
| GHRP-2 | pralmorelin, growth hormone-releasing peptide-2, KP 102 | Yes | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
| Capromorelin | CP-424391, Entyce | No | Unknown No pharmacokinetics source was retrieved in v1. PubChem does not carry half-life as a property, so this is recorded as not yet sourced rather than estimated. |
| Ghrelin | acyl ghrelin, growth hormone-releasing acylated peptide | Yes | Withheld pending qualified review |
4 of 8 compounds in this class are withheld pending qualified review, so their reported values are not shown here and their pages are not published. They are listed because the class is incomplete without them.
Where this page sits
Research records for compounds in this class
- Records indexed for Ipamorelin
- Records indexed for GHRP-6
- Records indexed for Hexarelin
- Records indexed for Ibutamoren
- Records indexed for AOD9604
- Records indexed for GHRP-2
- Records indexed for Capromorelin
- Records indexed for Ghrelin
Side-by-side pages within this class
All classes: class index. All compounds: compound index.
Sources
- Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren. Nat Commun (2021). pmid:34737341
- Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol (1998). pmid:9849822
- Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor. Mol Endocrinol (2001). pmid:11518797
On each stated value was matched to the record cited for it. That is record matching, not an appraisal of the research. Compiled and checked by: Peptide Monographs editorial desk. No qualified clinical reviewer.